Exercise promotes bone marrow microenvironment by inhibiting Adipsin in diet-induced obese mice

To study how exercise induces bone remodeling in diet-induced obesity in a comprehensive way.8-week male C57/B6 mice were fed with HFD to establish an obese mice model. Then mice were randomly divided into 2 groups: the exercise and the control groups. The exercise group of mice was put on a moderate-intensity treadmill running for 12 weeks.We employed unbiased RNA-Seq to comprehensively investigate the exercise effect on the bone marrow of diet-induced obesity mice in vivo. Overall design: To investigate how exercise induces bone remodeling in diet-induced obesity in a comprehensive way, we isolated the bone marrow from the the control and the exercise group tibia after 12-weeks exercise intervention and analyzed them by RNA-seq.