LSD1(KDM1A)-CoREST in complex with 1-Ethyl-Tranylcypromine
收藏Protein Data Bank Japan2024-01-10 更新2026-03-21 收录
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https://pdbj.org/mine/summary/4uv9
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LSD1(KDM1A)-CoREST in complex with 1-Ethyl-Tranylcypromine Descriptor: LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(4aS,10aS)-4a-[(1S,3E)-3-imino-1-phenylpentyl]-7,8-dimethyl-2,4-dioxo-1,3,4,4a,5,10a-hexahydrobenzo[g]pteridin-10(2H)-yl]pentyl dihydrogen diphosphate Authors: Vianello, P, Botrugno, O, Cappa, A, Ciossani, G, Dessanti, P, Mai, A, Mattevi, A, Meroni, G, Minucci, S, Thaler, F, Tortorici, M, Trifiro, P, Valente, S, Villa, M, Varasi, M, Mercurio, C. Deposit date: 2014-08-05 Release date: 2014-09-10 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3 Å) Cite: Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A. Eur.J.Med.Chem., 86C, 2014
创建时间：
2014-08-05
