Cep135 deficiency promotes cell cycle de-regulation, p53 accumulation and cell deah of neural progenitors

Gene expression profiles of Cep135 wildtype and knockout E14.4 and E11.5 mouse embryonic neocortices. Gene expression profiles of in vitro E14.5 cortices-derived primary neurospheres are also included; in vitro samples listed as "12h" or "24h" depending on the duration of the in vitro culture from NPs isolation for incipient neurosphere formation and RNA isolation for RNAseq. E11.5 and E14.5 embryos resulting from matings between cep135 (+/-) mice were sacrificed and dorsal telencephalons dissected out to RNA isolation and RNAseq analysis. In the case of E14.5 telencephalons, E14.5 cortical neural progenitors were also isolated and cultured for 12 and 24h for the formation of incipient neurospheres. RNAseq analysis of these in vitro cultures is also available.