Typical gene ontology (GO) annotations significantly enriching the human subsets of transcripts and genes overexpressed in both the GBM tumor and normal brain, the normal brain overall or the normal brain only.

The P-value of a given enrichment is calculated assuming hypergeometric probability distribution of the annotations among the transcripts or genes in the global set, and of the subset of annotations among the subset of transcripts or genes, . These enrichments of the subsets at the overexpression cutoff of are consistent with the enrichments of the corresponding subsets at the overexpression cutoffs of (Table S2 in Appendix S1). None of the multiple GO annotations consistently enrich the human subsets of transcripts and genes that are overexpressed in the GBM tumor only. None of the multiple GO annotations consistently enrich the human subsets of transcripts and genes that are overexpressed in the GBM tumor overall beyond those that enrich the subsets that are overexpressed in both the GBM tumor and normal brain.