Expression data comparing Normal Human Bronchial Epithelial Cells (NHBE) cells in states of senescence, proliferation and quiescence

EGFR inhibitor Erlotinib treatment can induce NHBE into profound cell cycle arrest that include senescence and quiescence. Because senescent cells feature high senescence assocaited-beta-galactosidase(SA-β-gal) activty, which has been used as marker for FACS based collection of senescent and quiescent cells, respectively. After FACS sorting based on SA-β-gal activty, control (DMSO treated), quiescent (Erlotinib treated), senescent NHBE cells (Erlotinib treated) have been selected for RNA extraction and hybridization on Affymetrix microarray. We aimed to explore genes, the expression of which are specifically changed in senescence group (Erlotinib-SE), while remain similar expression pattern in both control (DMSO-CON) and quiescence (Erlotinib-Q) group.