Aging-induced changes in sperm DNA methylation contribute to abnormal social behavior in offspring (PRJCA018864)

Advanced paternal age is a significant risk factor for neurodevelopmental disorders in offspring, including schizophrenia, autism, and abnormal social behavior, etc. However, the underlying mechanisms remain poorly understood. In this study, we investigated the impact of aging on sperm DNA methylation patterns in male mice and identified a total of 4054 Differential Methylated Regions.