Comparison of the whole transcriptomes between ALS-mutant and Healthy control motor neurons. Comparison of the whole transcriptomes between ALS-mutant and Healthy control motor neurons

We performed total RNA sequencing to analyze and compare the whole transcriptomes of hiPSC-derived motor neurons obtained from ALS patients harboring mutations in the C9orf72 (2 patients) and FUS (2 patients) genes, and from control hiPSC lines. The Healthy control cells were obtained from 1 healthy individual, and by correcting the pathogenic mutation within C9orf72 gene with Crispr technology Overall design: Whole transcriptome analysis of 35 days old motor neurons