OSGIN1

This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]

本基因编码一种调节细胞死亡的氧化应激反应蛋白。该基因的表达受p53调控，并在DNA损伤诱导下被激活。该蛋白通过诱导线粒体中细胞色素c的释放来调节细胞凋亡。此外，该蛋白似乎也是调控炎症和抗炎分子的重要调节因子。该蛋白的缺失与细胞无序生长和肿瘤形成密切相关。该基因与其上游的丙二酰辅酶A脱羧酶（MLYCD）基因之间存在自然发生的读通转录，但读通转录本不太可能产生蛋白质产物。 [提供者：RefSeq，2011年8月]