Exploration of SQC formula effect on Type 2 diabetes mellitus by whole transcriptome profile in rats

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease that has turned up as pandemic dimensions all over the world. In China, some traditional Chinese herbal formulas have enjoyed a high reputation in T2DM treatment for centuries. And ShenQi compound (SQC), a formula has been performed on T2DM clinical therapeutics in China for many years, deserve to study in depth. Gene microarray experiments were performed to explore the molecular mechanism of SQC treatment. In addition, a western medicine, metformin was employed as a comparison. The rats were divided into four groups including control group(3 rats), model group(3 rats), metformin group(3 rats) and SQC group(3 rats,SQC dose:1.44 g/kg*5 per day, once a day for 8 weeks). Then gene microarray experiments were performed.