CSP+K — HRV summary dataset & analysis code (v1.5.0 REPRO)

Japanese summary本パッケージは、論文本文の主要臨床解析(患者レベル**≥80% responder**、非調整ARD+Newcombe 95%CI+Fisher)に整合したHRV支持解析(AAW)の再現アーカイブです。臨床個票は含まず、HRVの要約データと実行コードのみを配布します。本文のセッション判定は階層ルール(同日優先/同日が無ければ次回受診)で定義されており、本パック内では参照のみ明記します(臨床データは配布しません)。 English (primary) Title. CSP+K HRV supportive dataset & code — v1.5.1 (REPRO) Scope & alignment. This repository distributes HRV supportive physiology only for the CSP+K program. It aligns with the manuscript’s design posture: the primary clinical endpoint is patient‑level responder = ≥80% of rated sessions “improved”, with session ratings captured via a hierarchical source rule (same‑day pre‑discharge preferred; else first follow‑up explicitly attributing the index session). The clinical endpoints are not distributed here; this pack contains anonymized HRV summary counts and reproducible code implementing design‑based contrasts (AAW = ΔHR<0 ∧ ΔRMSSD>0; Newcombe 95% CIs; two‑sided Fisher). What’s included. data/ HRV summary tables (same‑session pairs; pooled 3‑ and 5‑min; ≤5% artifact; ≤3% HQ subset). code/analysis.py Reproducible analysis producing AAW risk differences (Newcombe 95% CIs) & Fisher p and PNG bar plots. docs/SAP_v1.5.0.md Statistical Analysis Plan (supportive HRV only); CODEBOOK.md; SOP_excerpt.md. CITATION.cff (Concept DOI) and dual licenses (LICENSE-CODE, LICENSE-DATA). How to reproduce. python -m pip install -r code/requirements.txtpython code/analysis.py# outputs:# code/Summary_RD_Newcombe.csv# code/figures/bar_overall.png, bar_3min.png, bar_5min.png Analytical posture. No covariate adjustment / no model‑based regression. We report absolute risk differences (ARD) with Newcombe 95% CIs and Fisher’s exact p‑values; design‑based robustness only. This mirrors the manuscript’s unadjusted, patient‑level primary analysis (responder = ≥80% improved under an IV‑dominant assignment). Versioning & DOIs. Concept DOI (cite in manuscript): 10.5281/zenodo.1739113110 Version DOI (this snapshot): (auto‑assigned on publish; add here after release)The Supplement cites the Version DOI for this exact snapshot; the article cites the Concept DOI. Licensing. Code and data use separate licenses; see LICENSE-CODE and LICENSE-DATA. How to cite. Cite the Concept DOI above and the article:“Association of high‑thoracic epidural priming with higher effectiveness at lower ketamine dose in outpatient care: a single‑center cohort.” (MCPIQO, Original Research). The cover letter and manuscript explicitly present the patient‑level ≥80% responder definition and unadjusted ARD with Newcombe CIs. What’s new in v1.5.1. Fixed the analysis runner; clarified alignment with the manuscript (patient‑level ≥80%, hierarchical rating source); removed S‑ROB1/logistic/IPTW mentions; design‑based RD + Newcombe + Fisher only (no data changes). Package structure (excerpt). CSPK_HRV_Public_v1.5.1_REPRO/ README.md, VERSION, CHANGELOG.md, CITATION.txt, CITATION.cff code/ analysis.py # design-based RD (Newcombe 95% CI) + Fisher; outputs CSV & PNGs requirements.txt figures/ # outputs appear here data/ cspk_hrv_pairs_v1.4.csv hrv_counts_by_length_v1.4.csv hrv_counts_overall_v1.4.csv docs/ SAP_v1.5.0.md SOP_excerpt.md CODEBOOK.md Keywords. HRV; RMSSD; ketamine; cervical epidural; outpatient; design‑based inference; absolute risk difference; Newcombe CI; Fisher exact; real‑world evidence.