Synthesis of a Reaction Intermediate Analogue of Biotin-Dependent Carboxylases via a Selective Derivatization of Biotin
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https://figshare.com/articles/dataset/Synthesis_of_a_Reaction_Intermediate_Analogue_of_Biotin-Dependent_Carboxylases_via_a_Selective_Derivatization_of_Biotin/3759582
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资源简介：
An efficient and practical synthesis of 1, a unique reaction intermediate analogue of biotin-dependent carboxylases, is described. The synthesis
features a selective acylation of the 1‘-N of biotin. Target 1 inhibits the activity of the biotin carboxylase component of acetyl CoA carboxylase.
It is the first known biotin-derived inhibitor of biotin carboxylase and should promote new kinetic and structural studies of the biotin-dependent
carboxylases.
创建时间：
2016-08-26
