Figure_1.jpg

MTT viability assay for determining the doses of ZOL (A), GGOH (B), and PFA (C) to use in rescue assays. (D) ZOL-induced viability loss rescue assay results where UN indicates untreated (set to 100% viability), ZOL indicates 50 microM ZOL. GG10 and GG30 indicate 10 microM and 30 microM of GGOH, respectively. Error bars represent SEM with the double asterisk ** or the plus + indicating p less than or equal to 0.01 and the triple asterisk *** or the hash # indicating p less than or equal to 0.001. Significant difference comparisons include panels A-C: doses significantly lower than their respective vehicle control and panel D: ZOL significantly lower than ZOL vehicle plus each of GG10 + ZOL and GG30 + ZOL significantly higher than ZOL.