官方服务：
资源简介：
investigation of NUAK1 using KPC-CDX model and NUAK1 inhibitor. KPC model is KPC cell subcutaneous transplantation mouse model. HTH-01-015 and WZ4003 are used as NUAK1 inhibitor.
应用场景：
创建时间：
2023-03-11
相关数据集
Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs
Prospective predictions of human hepatic clearance for anionic/zwitterionic compounds, which are oftentimes subjected to transporter-mediated uptake, are challenging in drug discovery. We evaluated th
NIAID Data Ecosystem40
The influence of age and sex on the pre-treatment immune microenvironment of a carcinogen induced murine model of bladder cancer
The incidence of urothelial carcinoma of the bladder is four times higher in males than females; however, females tend to present with a more aggressive disease, a poorer response to immunotherapy and
NIAID Data Ecosystem40
The HDAC inhibitor panobinostat (LBH589) inhibits Acute Lymphoblastic leukemia (ALL) in vitro and in vivo in a new characterized human ALL mice model (ALL-B and ALL-T). Homo sapiens
Histone deacetylases (HDACs) have been identified as therapeutic targets due to regulatory function in DNA structure and organization. We have analyzed the role of the LBH589, a novel pan inhibitor of
NIAID Data Ecosystem10
Targeting mTOR and Src restricts hepatocellular carcinoma growth in a novel murine liver cancer model
Liver cancer is a poor prognosis cancer with limited treatment options. To develop a new therapeutic approach, we derived HCC cells from a known model of murine hepatocellular carcinoma (HCC). We trea
NIAID Data Ecosystem40
Childhood Cancer Data Initiative (CCDI): PIVOT Children's Cancer Institute Australia. Childhood Cancer Data Initiative (CCDI): PIVOT Children's Cancer Institute Australia
The goal of this study is to molecularly characterize a large panel of pediatric acute lymphoblastic leukemia (ALL) patient-derived xenografts (PDXs) previously established in immune-deficient mice. T
NIAID Data Ecosystem20
