Elution profiles and protein interaction data accompanying "Ancient eukaryotic protein interactions illuminate modern genetic disorders"

DESCRIPTION FILENAME LOCATION LECA 10K OG set TableS1-LECA_OGs_annotated.csv Paper, Table S1 Zenodo Summary of biological resources resource_summary.xlsx STAR Methods LECA interactome (complexes) leca_ppis_fdr10_clustered_annotated.xlsx Paper, Table S2 Zenodo CFMS - ref proteomes cfms_ref_proteomes.xlsx Paper, Table S3 Zenodo ML - top algorithms tpot_top_algorithms.xlsx Paper, Table S4 Zenodo LECA interactome (pairwise) leca_ppis_fdr10_pairwise.csv Zenodo UniProt Subcellular Localization IDs uniprot_localization_codes.xlsx Zenodo Dollo parsimony - ref proteomes dollo_parsimony_ref_proteomes.xlsx Zenodo Dollo parsimony - input trait matrix dollo_parsimony_count_matrix.tsv Zenodo CFMS - raw elution profiles amorphea_raw_elution_vectors.csv excavata_raw_elution_vectors.csv tsar_raw_elution_vectors.csv archaeplastida_raw_elution_vectors.csv Zenodo CFMS - normalized elution profiles amorphea_norm_elution_vectors.csv excavata_norm_elution_vectors.csv tsar_norm_elution_vectors.csv archaeplastida_norm_elution_vectors.csv Zenodo CFMS/APMS - complete feature matrix feature_matrix.csv Zenodo ML - top features linearsvc_top_100_features.xlsx Zenodo OMIM disease propagation, statistics omim_disease_propagation_stats.xlsx Zenodo OMIM disease propagation, top 20 hits per disease omim_disease_propagation_top20hits_per_disease.xlsx Zenodo Curated OMIM gene-disease relationships for LECA OGs omim_disease_network.tsv Zenodo Curated OMIM gene-disease relationships for human UniProt IDs omim_disease_groups.csv Zenodo Summary of mass spectrometry results for each orthogroup by eukaryotic supergroup SummaryofMSSupportbySupergroup.xlsx Zenodo Summary of phenotype predictions in yeast and Chlamydomonas LECA_yeast_Chlamy_gene-phenotype-predictions.xlsx Zenodo Chlamydomonas mutant phenotype gene sets Chlamy_mutant_phenotype_gene_sets.tsv Zenodo Yeast mutant phenotype gene sets Yeast_mutant_phenotype_gene_sets.tsv Zenodo Binarized species tree for Notung analysis speciestree_binary_internalnodes.nhx Zenodo Notung calls for "famPresent" at 70% confidence DTL70_famPresent.txt Zenodo Notung calls for "origin" at 70% confidence DTL70_origin.txt Zenodo Notung DTL-reconciled trees at 70% confidence DTL70_trees.zip Zenodo Notung calls for "famPresent" at 90% confidence DTL90_famPresent.txt Zenodo Notung calls for "origin" at 90% confidence DTL90_origin.txt Zenodo Notung DTL-reconciled trees at 90% confidence DTL90_trees.zip Zenodo