Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development

Genome binding/occupancy profiling was carried out by high throughput sequencing in human developmental cortical interneurons and developmental glutamatergic neurons derived from healthy control vs schizophrenia iPSCs Overall design: Open chromatin profiles (ATAC-seq assay) in human developmental cortical interneurons (MGE organoid) and glutamatergic neurons (CO organoid) derived from healthy control vs schizophrenia iPSCs