Pathogenic LMNA variation disrupts a tissue-specific lamina-chromatin signature, resulting in loss of cellular identity
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
We demonstrate that a normal function of lamina-associated chromatin is to maintain silencing of undesired lineages, and laminopathies, like LMNA T10I and R541C, may specifically target these regions, resulting in predictable tissue-specific nuclear architecture changes during development.
提供机构：
University of Pennsylvania Perelman School of Medicine
创建时间：
2022-02-20
