Pathogenic LMNA variation disrupts a tissue-specific lamina-chromatin signature, resulting in loss of cellular identity

Name: Pathogenic LMNA variation disrupts a tissue-specific lamina-chromatin signature, resulting in loss of cellular identity
Creator: University of Pennsylvania Perelman School of Medicine
Published: 2022-02-20T00:00:00+08:00

干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录

基因突变

细胞身份

数据链接：

http://data.iscr.ac.cn/Article?id=1f789000dc1253843284e93bdcc3a704 数据链接链接失效反馈

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资源简介：

We demonstrate that a normal function of lamina-associated chromatin is to maintain silencing of undesired lineages, and laminopathies, like LMNA T10I and R541C, may specifically target these regions, resulting in predictable tissue-specific nuclear architecture changes during development.

提供机构：

University of Pennsylvania Perelman School of Medicine

创建时间：

2022-02-20