MOESM10 of ALS blood expression profiling identifies new biomarkers, patient subgroups, and evidence for neutrophilia and hypoxia

Additional file 10. DEG lists and annotation-based enrichment analyses. (A) List of 752 ALS-increased DEGs (FDR < 0.10, FC > 1.10). (B) List of 764 ALS-decreased DEGs (FDR < 0.10, FC < 0.909). (C) GO BP increased DEGs. (D) GO BP decreased DEGs. (E) GO BP increased DEGs + decreased DEGs. (F) GO CC increased DEGs. (G) GO CC decreased DEGs. (H) GO CC increased DEGs + decreased DEGs. (I) GO MF increased DEGs. (J) GO MF decreased DEGs. (K) GO MF increased DEGs + decreased DEGs. (L) KEGG increased DEGs. (M) KEGG decreased DEGs. (N) KEGG increased DEGs + decreased DEGs. (O) REACTOME increased DEGs. (P) REACTOME decreased DEGs. (Q) REACTOME increased DEGs + decreased DEGs. (R) DO increased DEGs. (S) DO decreased DEGs. (T) DO increased DEGs + decreased DEGs. (U) MSigDB increased DEGs. (V) MSigDB decreased DEGs. (W) MSigDB increased DEGs + decreased DEGs. (X) Pathway commons increased DEGs. (Y) Pathway commons decreased DEGs. (Z) Pathway commons increased DEGs + decreased DEGs. In (C)–(Z), spreadsheets list annotation terms most significantly enriched with respect to ALS-increased DEGs, ALS-decreased DEGs, or the combined set of ALS-increased + ALS-decreased DEGs (p-values: conditional hypergeometric test or Fisher’s exact test). The final column in each spreadsheet lists DEG symbols associated with each annotation term.