List of mutation-intolerant (n = 34) and mutation-tolerant (n = 533) disordered regions (IDRs) identified in this study.

For each IDR, the table lists the DisProt identifier, name of the gene encoding for the IDP, length of the disordered region, and the annotation of disorder function, interaction partner, structural state, and structural transition of the IDR, when available in the DisProt database. Further, we report the number of “pathogenic” (ClinVar database) and “population” (gnomAD database) mutations that are located in each IDR, followed by the diseases associated with the germline pathogenic mutations affecting the IDR. (XLSX)