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The role of TERT gene in AD models
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创建时间：
2020-05-20
相关数据集
Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology. Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology
Polygenic risk scores have identified that genetic variants without genome-wide significance still add to the genetic risk of developing Alzheimer’s disease (AD). Whether and how subthreshold risk loc
NIAID Data Ecosystem40
Data_Sheet_1_Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease.docx
The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are important nitrogen donors for synthesis of glutamate, the main excitatory neurotransmitter in the brain. The glutamate carbon
NIAID Data Ecosystem20
Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model
This dataset allows for the exploration of microglial function on gene expression in wild-type and the 5xFAD mouse model of Alzheimer's disease, across multiple brain regions. Mice were treated with t
NIAID Data Ecosystem10
Table_6_Network pharmacology analysis reveals neuroprotective effects of the Qin-Zhi-Zhu-Dan Formula in Alzheimer’s disease.xlsx
There is yet no effective drug for Alzheimer’s disease (AD) which is one of the world’s most common neurodegenerative diseases. The Qin-Zhi-Zhu-Dan Formula (QZZD) is derived from a widely used Chinese
NIAID Data Ecosystem20
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation
The hemizygous R47H variant of TREM2, a microglia-specific gene in the brain, increases risk for late-onset Alzheimer's disease (AD). Using transcriptomic analysis at the single-nuclei level from brai
NIAID Data Ecosystem10
