Single cell RNA-seq of adult mouse heart endothelial transcriptomes following myocardial infarction

A better understanding of the pathways that regulate regeneration of the coronary vasculature is of fundamental importance for the advancement of strategies to treat patients with heart disease. By analyzing single cell transcriptome of resident cardiac endothelial cells (ECs) in adult mouse hearts under both healthy and myocardial infarction (MI) settings, we provide molecular definitions of murine cardiac endothelial heterogeneity and characterizations of pro-angiogenic resident ECs.

深入解析调控冠状血管再生的信号通路，对于优化心脏疾病治疗策略具有至关重要的基础意义。本研究通过分析健康状态与心肌梗死（myocardial infarction, MI）环境下成年小鼠心脏内驻留心脏内皮细胞（cardiac endothelial cells, ECs）的单细胞转录组，从分子层面明确了小鼠心脏内皮细胞的异质性，并对促血管生成驻留内皮细胞进行了系统的特征表征。

搜集汇总

背景与挑战

背景概述

该数据集是一个单细胞RNA测序数据集，专注于成年小鼠在心肌梗死（MI）后心脏内皮细胞的转录组分析。它包含8个样本，其中4个来自MI条件，4个来自健康条件，使用Illumina HiSeq 4000平台进行测序，旨在揭示心脏内皮细胞的异质性并鉴定促血管生成的驻留内皮细胞，为心脏疾病的治疗策略提供分子基础。