Crystal structure of SARS-CoV-2 main protease M49T mutant in complex with leritrelvir
收藏Protein Data Bank Japan2026-06-24 更新2026-06-30 收录
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Crystal structure of SARS-CoV-2 main protease M49T mutant in complex with leritrelvir Descriptor: (3~{S},3~{a}~{S},6~{a}~{R})-2-[(2~{S})-2-cyclohexyl-2-[2,2,2-tris(fluoranyl)ethanoylamino]ethanoyl]-~{N}-[(2~{S})-4-(cyclopentylamino)-3,4-bis(oxidanylidene)-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]butan-2-yl]-3,3~{a},4,5,6,6~{a}-hexahydro-1~{H}-cyclopenta[c]pyrrole-3-carboxamide, 3C-like proteinase nsp5, GLYCEROL Authors: Huang, X, Li, Q, Yang, Z, Zhong, N, Xiong, X. Deposit date: 2026-02-11 Release date: 2026-06-03 Last modified: 2026-06-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Enhanced Target Binding by Leritrelvir Restores Dimerization of Mpro Mutants and Mitigates Drug Resistance Biorxiv, 2026
创建时间：
2026-02-11
