Mouse ear tissue at 2 days post immunization. Mouse ear tissue at 2 days post immunization

Gene expression analysis using nCounter immunology panel for profiling among naïve controls and immunized treatment samples. We explored the interplay between type-I IFNs and the development of host protective Th1 immunity in mice immunized with LmCen-/- parasites and challenged with L. donovani parasites and show that downregulation of IRF7 mediated production of IFN-α/β is critical for the induction of protective immunity. Overall design: In this study, using transcriptomics, we present differential gene exression to evaluate early immune response conditions upon immunization.