官方服务：
资源简介：
The DAF (deaminase free)-CBE/TBE efficiently converts C/T to G in mammalian cells
应用场景：
创建时间：
2023-08-03
相关数据集
Plant genome editing with different CBEs systems
Plant protoplast HTS data with different CBEs systems
NIAID Data Ecosystem70
Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope. Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope
Base editors are RNA-guided deaminases that enable site-specific nucleotide transitions. The targeting scope of these Cas-deaminase fusion proteins critically depends on the availability of a protospa
NIAID Data Ecosystem40
A General Theoretical Framework to Design Base Editors with Reduced Bystander Effects
To assist in the design of these optimized editors, we propose a discrete-state stochastic approach to build an analytical model that explicitly evaluates the probabilities of editing the target base
NIAID Data Ecosystem10
A DddA ortholog-based and transactivator-assisted nuclear and mitochondrial cytosine base editors with expanded target compatibility. Homo sapiens
Bacterial double-stranded DNA (dsDNA) cytosine deaminase DddAtox-derived cytosine base editor (DdCBE) and its evolved variant, DddA11, guided by transcription-activator-like effector (TALE) proteins,
NIAID Data Ecosystem60
Precise kilobase-scale genomic insertions in mammalian cells using PASTE
Programmable gene integration (PGI) technologies are an emerging modality withessential for exciting applications toin both basic research and translational development. Programmable addition via site
NIAID Data Ecosystem10
