The LB-vaccine induces high degree of protection in mice against challenge with spirochetes expressing OspA serotype 1, 2 or 5.

Protection against challenge with B. burgdorferi (experiments 1 and 2), B. afzelii (experiments 3 and 4) and B. garinii (experiments 5 and 6) is shown. B. afzelii infected ticks were used for challenge in experiments 3 and 4, and only data from mice where at least one fully fed tick was collected are presented. The p-values were calculated with Fisher’s exact test (two tailed); * p<0.05, ** p<0.01 and *** p<0.001. The LB-vaccine induces high degree of protection in mice against challenge with spirochetes expressing OspA serotype 1, 2 or 5.