29 By BP

1.Study introduction: EEG data were collected in two separate blocks in the same session. In each block, we used between 12 and 15 levels of laser energy (from 1 J to 3.75–4.5 J, in step of 0.25 J), and we delivered five laser pulses of each energy, for a total of 60–75 laser stimuli per block (120–150 in total). The different number of laser energy levels was due to the fixed lower limit (1 J) and the variable upper limit (3.75–4.5 J) needed to achieve a rating of 8 out of 10 in each participant. 2.Participant task information: Participants received laser stimulation and used the NRS scale to select a rating from 0 to 10.
3.Participant instructions: Participants were instructed to focus on the laser stimuli, keep their eyes open, receive the laser stimulation, and provide ratings. The order of stimulus energies was pseudorandomized, and the interstimulus interval varied randomly between 10 and 15 seconds using a rectangular distribution. An auditory tone delivered between 3 and 6 seconds after the laser pulse (rectangular distribution) prompted participants to rate the intensity of pain perception elicited by the laser stimulus.
4.References and links: Hu L, Cai MM, Xiao P, Luo F, Iannetti GD. Human brain responses to concomitant stimulation of A”─ and C nociceptors. J Neurosci. 2014 Aug 20;34(34):11439-51. doi: 10.1523/JNEUROSCI.1355-14.2014. PMID: 25143623; PMCID: PMC6615513. 5.Comments: