Histone modification changes during RASMCs' transformation into macrophage-like cells

We report histone modification status of H3K4me1, H3K4me2, H3K4me3 and H3K27ac within rat vascular smooth muscle cell at de-differentiated state (induced by DAPT treatment), inflammatory state (induced by cholesterol treatment) and macrophage-like state (induced by combined treatment of DAPT and cholesterol) Primary rat aortic smooth muscle cells were treated by NOTCH inhibitor DAPT, soluble cholesterol or both of them for 48 hrs to achieve cell state transformations