Single-Cell Analysis of Placenta Accreta Spectrum: Novel Contribution of Endothelial Cells to the Pathogenesis of Disease

This study utilizes advances in single-cell RNA-sequencing to generate transcriptomes from placenta accreta and control specimens. Overall design: For each of 3 accreta placentas, a biopsy was taken at the site of deepest invasion, AI (accreta invasive), and a site opposite of AI in the same placenta where it was attached normally, AO (accreta opposite). AI and AO from three accreta participants were compared to placental biopsies from three control (C) participants.