Hierarchical mechanisms for transcription factor-mediated reprogramming of fibroblasts to neurons. Hierarchical mechanisms for transcription factor-mediated reprogramming of fibroblasts to neurons

Here we reveal a hierarchical mechanism in the direct conversion of fibroblasts into induced neuronal (iN) cells mediated by the transcription factors Ascl1, Brn2, and Myt1l. Overall design: Examination of global transcriptional changes and mapping genome-wide transcription factors occupancy at distinct time points during the transdifferentiation process