Crystal structure of bRaf in complex with inhibitor
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Crystal structure of bRaf in complex with inhibitor Descriptor: 3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide, IODIDE ION, Serine/threonine-protein kinase B-raf Authors: Yin, J, Eigenbrot, C, Wang, W. Deposit date: 2020-06-28 Release date: 2021-05-26 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.493 Å) Cite: Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3 H )-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor. J.Med.Chem., 64, 2021
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2020-06-28
