Sox9 directs divergent epigenomic states in brain tumor subtypes (RNA-Seq)

The goal of this study was to profile gene expression differences between autochthonous mouse models of high-grade glioma (HGG) and ependymoma (EPN). Furthermore, with the objective of how transcription factor Sox9 affect gene expression in these two models, we also profiled gene expression differences between HGG and EPN after Sox9 overexpression (Sox9-GOF) or deletion (Sox9-LOF) in each of these models. Overall design: Comparative gene expression profiling analysis of RNA-seq data for mouse tumor tissue from HGG and EPN models.