Identification of the targets of the oxidative response repressor SisPerR in Saccharolobus islandicus REY15A

In our current study, SisPerR was revealed as a transcriptional repressor in response to oxidative stress in Saccharolobus islandicus REY15A. Deletion of sisperR abolishes the oxidative stress-induced expression of a large number of genes. To identify the target genes directly bound by SisPerR in vivo, chromatin immunoprecipitation-sequencing (ChIP-seq) was performed. Overall design: Chromatin immunoprecipitation-sequencing (ChIP-seq) for SisPerR was performed using anti-SisPerR antibody in Saccharolobus islandicus REY15A.