Classification of Disease Damage and Activity in CLE (JAAD) Supplemental Figures

Supplemental Figure 1. Representative patient clinical photographs demonstrating mild, moderate, and severe disease damage by CLASI-D strata. (A) A 40 year old female with facial lupus erythematosus tumidus (LET) lesions, classified as having mild disease damage (CLASI-D of 0-5). (B) A 23 year old female with disease damage from LET on bilateral thighs (left thigh pictured here) and hyperpigmentation and scarring on bilateral arms (not pictured), classified as moderate disease damage (CLASI-D of 6-16). (C) A 78 year old male with severe disease damage from DLE on scalp (CLASI-D of 17+). Patients have all signed written consent for photography.

Supplemental Figure 2. CLE subtypes in different severity groups of activity and damage. (A-B) Bar graphs compared different categories of CLE disease activity and damage in ACLE (n=28), SCLE (n=33), and DLE patients (n=179). (A) Damage severity was found to be significantly different among disease subtypes (p<0.0001). Patients with DLE were more likely to have severe disease damage. (B) Activity severity did not appear to be significantly associated with any particular subtype (p=0.36).

Abbreviations: ACLE: acute cutaneous lupus erythematosus; DLE: discoid lupus erythematosus; SCLE: subacute cutaneous lupus erythematosus

补充图 1. 通过 CLASI-D 层级展示轻度、中度和重度疾病损害的典型患者临床照片。 (A) 一名 40 岁女性患有面部红斑狼疮肿瘤性 (LET) 疣，被归类为轻度疾病损害（CLASI-D 评分为 0-5）。(B) 一名 23 岁女性双侧大腿（此处展示左侧大腿）患有 LET 疾病损害，以及双侧上臂的色素沉着和疤痕（未展示），被归类为中度疾病损害（CLASI-D 评分为 6-16）。(C) 一名 78 岁男性患有头皮盘状红斑狼疮 (DLE) 的重度疾病损害（CLASI-D 评分为 17+）。所有患者均已签署书面同意照像。

补充图 2. 不同活动性和损害程度组的 CLE 亚型。 (A-B) 柱状图比较了急性皮肤红斑狼疮 (ACLE)（n=28）、亚急性皮肤红斑狼疮 (SCLE)（n=33）和盘状红斑狼疮 (DLE) 患者（n=179）的 CLE 疾病活动性和损害的不同类别。(A) 损害严重程度在疾病亚型之间存在显著差异（p<0.0001）。DLE 患者更可能患有严重的疾病损害。(B) 活动严重程度似乎与任何特定亚型无显著关联（p=0.36）。

缩写：ACLE：急性皮肤红斑狼疮；DLE：盘状红斑狼疮；SCLE：亚急性皮肤红斑狼疮