A Prospective Study of Lifestyle, the Gut Microbiome, and Diverticulitis

By leveraging a large-scale collection of stool specimens (Micro-N) within the Nurses' Health Study II, we performed shotgun metagenomic sequencing and untargeted metabolomics profiling among 121 case women with a diagnosis of diverticulitis requiring antibiotics or hospitalization, with each matched to a control woman without diverticulitis during the same time period accounting for age, race, and month of stool collection (total N=242). We found microbiome and metabolomic profiles differed in diverticulitis cases compared to controls. Data deposited include metagenomic sequencing data (after removing the human sequences) and metabolomics data. ]]> The Nurses' Health Study II is an ongoing prospective cohort study of 116,429 female registered nurses residing across the U.S. aged 25-42 years at enrollment in 1989. Participants have been followed biennially by querying lifestyle, medical or other health-related information. Beginning in February 2019, a large-scale prospective collection of fecal and oral microbiome samples was launched, known as the Microbiome among Nurses (Micro-N) project. As of July 2021, a total of 14,992 women have returned a collection kit.]]>