Structure of BACE Bound to SCH745966
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Structure of BACE Bound to SCH745966 Descriptor: Beta-secretase 1, D(-)-TARTARIC ACID, N-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-[(2R,4R)-4-PHENOXYPYRROLIDIN-2-YL]ETHYL}-3-{[(2R)-2-(METHOXYMETHYL)PYRROLIDIN-1-YL]CARBONYL}-5-METHYLBENZAMIDE Authors: Strickland, C.O, Iserloh, U. Deposit date: 2007-07-16 Release date: 2008-03-18 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor. Bioorg.Med.Chem.Lett., 18, 2008
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2007-07-16
