five

Crystal Structure of EGFR T790M mutant in complex with naquotinib

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Protein Data Bank Japan2024-10-30 更新2026-03-21 收录
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Crystal Structure of EGFR T790M mutant in complex with naquotinib Descriptor: 6-ethyl-3-[[4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]oxy-pyrazin e-2-carboxamide, Epidermal growth factor receptor Authors: Mimasu, S, Tomimoto, Y, Maiko, I, Yasushi, A, Tatsuya, N. Deposit date: 2017-08-28 Release date: 2018-07-11 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Pharmacological and Structural Characterizations of Naquotinib, a Novel Third-Generation EGFR Tyrosine Kinase Inhibitor, inEGFR-Mutated Non-Small Cell Lung Cancer. Mol. Cancer Ther., 17, 2018
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2017-08-28
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