EGR1-dependent CDK5R1 gene expression

CDK5R1 (also known as p35) is a neuron-specific regulator of CDK5 that activates CDK5 kinase. The complex of CDK5:CDK5R1 is required for neurite outgrowth (Tsai et al, 1994; Lew et al, 1994; Nikolic et al, 1996; Xiong et al, 1997; Paglini et al, 1998). CDK5R1 expression is regulated in part by the binding of EGR1 to its cognate binding sites in the CDK5R1 promoter. EGR1 binding is stimulated by sustained NGF signaling and depends on activation of the ERK signaling pathway (Harada et al, 2001).

CDK5R1（亦称p35）是一种针对神经元的CDK5调控因子，能够激活CDK5激酶。CDK5与CDK5R1形成的复合体对于神经突生长至关重要（参见Tsai等，1994；Lew等，1994；Nikolic等，1996；Xiong等，1997；Paglini等，1998）。CDK5R1的表达部分受EGR1与CDK5R1启动子中同源结合位点的结合所调控。EGR1的结合受到持续的NGF信号刺激，并依赖于ERK信号通路的激活（Harada等，2001）。