Experimental pathway gene signatures and overlap with the MPH dataset.

a Pathway gene signatures were defined as all genes up or downregulated ≥ 2-fold across all 12 and 24 h time points, relative to untreated controls.
b IDs for PDGF, TGFβ, S1P, IL-13, IL-4, and RZN denote unique Agilent probe IDs. Entrez gene IDs were used for LPS, PolyIC, TNFα, IFNα, Iono-PMA, Dex, and imatinib; all genes represented by two or more probes were averaged in both the MPH dataset and individual gene signatures.
c The gene expression signature used for imatinib was determined based upon a p value cutoff, as defined by Chung, et al. [5].
d MPH overlap signifies the number of genes IDs from a given pathway also appearing in the MPH dataset; the low overlap percentages seen in both PDGF and PPARγ pathways is a result of platform differences, as both PDGF and PPARγ pathways were reanalyzed on Agilent 8 × 60k DNA microarrays, while the MPH dataset includes only probes present in both 44k and 60k arrays.
Experimental pathway gene signatures and overlap with the MPH dataset.