Metagenomic study of the effect of probiotics on hepatocellular tumor growth in mice. mouse gut metagenome

This study evaluated the efficacy of a novel mixed probiotic (Prohep) on hepatocellular tumor growth in mice and the relationships between tumor suppression, angiogenesis and modulation of Th17 cells and IL-17. We further applied whole genome shotgun metagenome sequencing to develop a molecular roadmap of the interactions between the probiotic-modulated gut microbiota and their metabolic products with the T-cell differentiation, secretion of anti-inflammatory cytokines and HCC tumorigenesis.