IGH 3'RR recombination uncovers a non-GC imprint and c-MYC-dependent IGH rearrangement activity in unmutated Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is an indolent non-Hodgkin lymphoma characterized by tumor B-cells that weakly express a B cell receptor (BCR). The great majority of CLL B-cells are unclass-switched expressing Ig of the mu/delta isotypes. This questions abnormalities in the Ig gene recombination machinery in CLL and we studied both CSR and LSR in CLL.