Intrauterine Botulinum Toxin A administration promotes thin endometrium regeneration in a manner dependent on regulatory effect of insulin-like growth factor-binding protein 3 on osteopontin proteolytic cleavage in mice

Intrauterine administration of BoTA might be a potential therapeutic strategy to promote endometrial regeneration via elevation of insulin-like growth factor binding protein 3 mediated osteopontin proteolytic cleavage To investigate differentially expressed genes in EtOH-treated thin endometrium compared to saline-treated control gourp, 3 independent uteri from EtOH-treated and saline-treated endometrium were obtained and compared.