Combined loss of Tet1 and Tet2 promotes B-cell, but not myeloid malignancies in mice
收藏官方服务：
资源简介：
Combined loss of Tet1 and Tet2 promotes B-cell, but not myeloid malignancies in mice
应用场景：
创建时间：
2015-11-12
相关数据集
Physical interaction between mutant calreticulin and the thrombopoietin receptor is required for transformation of hematopoietic cells
Somatic mutations in calreticulin (CALR) are present in approximately 40% of patients with myeloproliferative neoplasms (MPN). However, the mechanism by which mutant CALR is oncogenic is unknown. Here
NIAID Data Ecosystem100
Inactivation of KLF4 in T cell acute lymphoblastic leukemia promotes the expansion of leukemia cells by activating the Map2k7/Jnk pathway. [ChIP-Seq]
Chip-Seq analysis of bone marrow cells from control and Klf4 deficient T-ALL mice Overall design: GFP+CD4+CD8+bone marrow cells were sorted from control and Klf4 deficient T-ALL mice induced by NOTCH1
NIAID Data Ecosystem50
Characterisation of the myeloid differentiation process of human hematopoietic stem cells. Characterisation of the myeloid differentiation process of human hematopoietic stem cells
Hematopoietic stem cells (HSCs) can self-renew and/or differentiate into various functionally divergent progenitor cell types, such as common myeloid progenitors (CMPs), megakaryocyte-erythrocyte prog
NIAID Data Ecosystem40
Jarid2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells
How specific genetic lesions contribute to transformation of non-malignant myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS) to secondary acute myeloid leukemia (sAML) are poorly
NIAID Data Ecosystem70
RUNX1-EVI1 disrupts lineage determination and the cell cycle by interfering with RUNX1 and EVI1 driven gene regulatory networks [RNA-seq]
Hematological malignancies are characterised by a block in differentiation, which is in many cases caused by recurrent mutations affecting the activity of hematopoietic transcription factors. RUNX1-EV
NIAID Data Ecosystem40
