Eosinophils suppress STAT1 signaling and modulate metabolism in infected muscle.

Microarray-based gene expression profiling of diaphragms of uninfected and infected WT and PHIL mice on 0, 2 and 7 days post IV infection. Pathways detected by GSEA to be enriched in (A) PHIL or (B) WT mice at 7 days post IV infection. (C) Selected genes from interferon signaling, TCA cycle and fatty acid metabolism pathways. Maximum mean fold change (FC) between PHIL and WT at 7 days post IV infection is shown. Color pattern represents row Z-score.