Intrahepatic transcriptional signature associated with response to interferon-a treatment in the woodchuck model of chronic hepatitis B. Marmota monax

To define the intrahepatic cellular and molecular characteristics of the antiviral response to wIFN-alpha in woodchuck, the transcriptional profiles of woodchuck liver were studied by using RNASeq Overall design: Woodchucks liver samples with chronic woodchuck hepatitis virus (WHV) infection were treated with recombinant woodchuck IFN-alpha or with placebo for 26 weeks