Overexpression of Slc1a2 in the prefrontal cortex (PFC) region of male mice can effectively reverse the glutamate/GABA (gama - aminobutyric acid) - glutamine cycle disorder induced by sleep deprivation

This study reveals the role of communication between astrocytes and neurons in sleep deprivation. After sleep deprivation in the model mice, we observed a decrease in communication between astrocytes and neurons. Meanwhile, sleep deprivation significantly altered the distribution of cells and gene expression in the brainstem, cortex, and hypothalamus