Conserved Effects of alcohol on gut microbiota in both humans and non-human primates. human gut metagenome, rhesus macaques gut metagenome

Alcohol use disorder (AUD) is a complex brain disorder that presents with severe mental and physical impairment and serious harm to society and families. The specific etiology and pathogenesis of AUD are still unknown. Increasing studies suggest that the "microbiome-gut-brain axis" may be involved in the occurrence and development of AUD. Here, we studied the changes of intestinal microbiota between AUD patients and health control, the chronic alcohol-drinking groups and control groups of non-human primates (NHP), rhesus macaquess. The differential altered microbiota between these two groups of human and NHP were identified, respectively. Three microbiota at genus level, Prevotella, Ruminococcus and Phascolarctobacterium were significantly decreased in both AUD and chronic alcohol-drinking NHP. We also found that the relative aboundance of Ruminococcus was positive correlated with TBLB in both human and NHP. This is useful to support the essential role of gut microbiota in AUD across different species and provide ideal therapeutic target for AUD.