Supplemental Material for Morrison, Wonderlick, and Harms, 2021
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Mathematical derivations and proofs for work presented in the main text. The supplement has five sections: 1. Necessary conditions for ensemble epistasis2. Ensemble can lead to high-order epistasis3. Epistasis between mutations within conformations can co-exist with ensemble epistasis4. Ensemble epistasis can arise for ensembles with more than three conformations5. Modeling the calcium-dependence of ensemble populations for S100A4Fig S1: Demonstrates that our epistasis analysis is robust to our modeling choice for our deep-mutational scan of S100A4.
创建时间：
2021-06-22
