IC can inhibit T cell mediated macrophage activation in gmMφ.

gmMφ or mMφ and Tck were cultured from the same donor. (A) At day 6 the macrophages and Tcks were harvested, washed and cultured together in a ratio of 1∶5. TNFα and IL-10 were measured in the supernatant after 20 hours. Bars are mean and SEM from 3 independent experiments. (B) gmMφ were cultured alone or in a 1∶5 ratio with Tck in the presence or absence of ICs (50 µg/ml) for 20 hours before collecting the supernatant. Bars are mean and SEM from 6 independent experiments. *P<0.05, NS is not significant.