Patterns of Reactivity. Antibodies corresponding to each of the epitopes were investigated through ELISA against peptides of the same sequence (“Pep” column) as well as spike glycoproteins from the indicated sources. For the peptide ELISAs, green indicates a mean IgG titre of over 1:100 for at least two of the three immunized mice; red indicates a mean IgG titre of over 1:100 for at least two of the three immunized mice. Group I, non-immunogenic epitopes; Group II, non-reactive with parent protein; Group III, recognition of sequence conserved epitopes in non-parent protein; and Group IV, recognition non-conserved epitopes. CS = conserved epitope sequence; DS = divergent epitope sequence.

Patterns of Reactivity. Antibodies corresponding to each of the epitopes were investigated through ELISA against peptides of the same sequence (“Pep” column) as well as spike glycoproteins from the indicated sources. For the peptide ELISAs, green indicates a mean IgG titre of over 1:100 for at least two of the three immunized mice; red indicates a mean IgG titre of over 1:100 for at least two of the three immunized mice. Group I, non-immunogenic epitopes; Group II, non-reactive with parent protein; Group III, recognition of sequence conserved epitopes in non-parent protein; and Group IV, recognition non-conserved epitopes. CS = conserved epitope sequence; DS = divergent epitope sequence.