GLP-1 reduced pro-fibrotic molecules in HF- or HG-stimulated cardiomyocytes.

(a) GLP1R expression in the GK model (left) (n=5, each group), and HL-1 stimulated cardiomyocytes (right). A representative QPCR-amplification plot of each rat or stimulated cell is also showed. (b) Intracellular (by WB and IF) and (c) secreted levels of fibronectin (FN) in GLP-1-pre-treated cardiomyocytes exposed to HF (0.25 mM) or HG (33 mM). (d) Pro-fibrotic expression (TGFß1 and CTGF) in stimulated cardiomyocytes. *p<0.05 and **p<0.01 vs. control. †p<0.05 and ††p<0.01 vs. HF or HG.